摘要
目的探讨胃癌患者血清胃蛋白酶原(pepsinogen,PG)Ⅰ、PGⅡ、PGⅠ/PGⅡ比值(PGR)、胃泌素(GAS)-17和MG7-Ag水平变化和临床意义。方法根据胃镜和组织病理学检查结果将149例胃镜受检者分为4组。①正常对照组:胃黏膜正常或示非萎缩性胃炎50例。②十二指肠溃疡组32例。③萎缩性胃炎伴肠化生及异型增生组27例。④胃癌组40例。分别对①～④组用ELISA方法定量测定血清GAS-17和MG7-Ag水平,同时以乳胶增强免疫比浊法定量测定PGⅠ、PGⅡ水平。结果胃癌组PGⅡ显著高于正常对照组(P<0.05),PGR显著低于正常对照组(P<0.01);进展期胃癌GAS-17和MG7-Ag水平均显著高于早期胃癌(P<0.05)。结论以PGⅠ≤70 ng/ml且PGR≤3.0为界值诊断胃癌的方法特异性好(93.6%),敏感性为17.5%。血清GAS-17和MG7-Ag水平变化与癌肿分化程度有关,其值越高,预后越差。
Objective To explore the clinical value of determination of serum pepsinggen,Gasrtin-17 and MG7-Ag for diagnosis of gastric.Methods A total of 149 patients were divided into 4 groups based on endoscopic and histopathological findings：32 patients in duodenal ulcer group,27 in atrophic gastritis group,40 in gastric cancer group,and 50（including mild non-atrophic gastritis） were served as control group.Gasrtin-17 and MG7-Ag were determianed by enzyme linked immunosorbent assay（ELISA）,serum pepsinggen was determianed by latex enhanced turbidimetric immunoassay.Results PGⅡlevel increased（P0.05） and PGR level decreased（P0.01） significantly in gastric cancer group.Gasrtin-17 and MG7- Ag values were significantly higher in patients with advanced gastric cancer than those with early cancer（P0.05 ）.Conclusion The method by using the cut-off value（PGⅠ≤70 ng/ml and PGR≤3） to diagnose gastric cancer is of good specificity （93.6%）,sensitivity 17.5%.Gasrtin-17 and MG7-Ag values are related to the degree of tumor differentiation and prognosis.
出处
《临床消化病杂志》
2011年第2期81-83,共3页
Chinese Journal of Clinical Gastroenterology
