慢性末端回肠炎患者小肠细菌过度生长情况的研究

A Study on Small Intestinal Bacterial Overgrowth in Patients of Chronic Terminal Ileitis

目的探讨慢性末端回肠炎(CTI)患者的小肠细菌过度生长(SIBO)情况,以及SIBO与其末端回肠炎症程度之间的关系。方法将98例CTI患者按末端回肠炎程度,分为轻度、中度、重度等3组,通过葡萄糖氢呼气试验(GHBT)分别检测其SIBO情况,并与健康对照组进行组间比较分析。结果 3组CTI患者与健康对照组的SIBO阳性率及试餐后呼气氢浓度比较均有显著差异(P<0.01)。CTI患者的SIBO阳性率及试餐后呼气氢浓度随着末端回肠炎症程度呈渐进性增高。各组间差异有显著性(P<0.05)。结论 CTI患者常存在SIBO,且随着末端回肠炎症程度的加重,其SIBO情况也加重。CTI患者的末端回肠炎症程度与其发生的SIBO之间有直接或间接的关联。

Objective To investigate the conditions of small intestinal bacterial overgrowth（SIBO） in patients of chronic terminal ileitis（CTI）,and the relationship between SIBO and inflammation degree of CTI patients.Methods According to the terminal ileum inflammation degree,98 cases divided into degree of mild,moderate,and severe three groups,through the glucose hydrogen breath test（GHBT） resepectively,comparisos and analyses were carried on them separately.Results Statistical differences in expiratory hydrogen concentrations and the postitive rate of SIBO were fond between CTI patients and health control subjects（P0.01）.The expiratory hydrogen concentrations and SIBO rates were rising bit by inflammation degree,there were statistical differenes among the three groups（P0.05）.Conclusion CTI patients often accompanied by SIBO,and the more inflammation degree of aggravating,the more serious SIBO will be.The inflammation degree of CTI patients may have a direct or indirect effect on SIBO.