急性结核菌感染所致冠状动脉损害的实验研究

Experimental study on coronary artery lesion in rabbit with acute tuberculous infection

目的 了解结核菌是否对冠状动脉造成损害。方法 以日本大耳白家兔为实验动物，Ｈ３７Ｒｖ 为实验菌株：一组家兔经钴＿６０ 辐射破坏免疫器官功能后静脉感染结核菌液（１０７／ｍｌ） ，一组家兔直接感染结核菌液。动物解剖后，脏器病理切片经Ｚ＿Ｎ 染色，ＨＥ 染色、三色（ＭＣＴ） 染色，ＢＣＧ 免疫组织化学染色和电镜观察。结果 结核菌随血行播散可到达心脏的任何部位并形成病变，冠状动脉的损害亦同样明显。免疫功能低下者将会导致结核的易感性和病变的严重性。结论 结核菌能导致冠状动脉的病理性损伤。

Objective To observe the coronary artery lesion that is led by Mycobacterium tuberculosis.Method Japanese rabbit were research infection animals.H 37 Rv was the research bacterium strain.One group rabbits were injected tuberculous solution,after Co_60 damaging immune system function,another group rabbite were directly injected tuberculous solution.We observed the lesions of heart,specially the coronary artery by pathological method,including Z_N dyeing,HE dyeing,three colour dyeig(MCT),BCG immunehistochemisty dyeing and electron microscope examination.Result The result show that Mycobacterium tuberculosis can to any place of heart by blood and form lesion.Severe damage was found in coronary artery.Immunization suppression rabbits will be resulted in susceptility to Mycobacterium tuberculosis and cause severe lesions.Conclusion Mycobacterium tuberculosis can cause the lesion of coronary artery.