122例复发肺结核病例化疗分析

A study on chemotherapy and drug resistance for 122 cases of relapse pulmonary tuberculosis

目的 分析１２２ 例痰培养阳性复发肺结核的耐药及化疗效果。方法 １９９５ ～１９９７ 年登记的复发肺结核病例痰培养阳性并作药物敏感试验，治疗方案为ＨＲＥＺ／ＨＲＥ。疗程中至少进行三次痰结核菌检查。结果 敏感组９１ 例，耐药组３１ 例，敏感组完成疗程时痰菌阴转率为８５－７ ％ ，耐药组痰菌阴转率为６７－７ ％ 。结论 复发肺结核病例如发生耐药，尤其是多耐药，治疗效果较对结核药物敏感者为差。积极治疗初治传染源，减少耐药病例的发生，对控制结核病具有重要意义。

Objective To analyse the antituberculosis_drug resistance and chemotherapy of sputum culture_positive in 122 cases with recurrent pulmonary tuberculosis(RPT).Methods Drug_susceptibility tests was done in sputum culture_positive cases with RPT between 1995 and 1997.HREZ/HRE was used as therapeutic scheme.Sputum examination for tubercle bacillus was performed three times at least.Results The sputum negative conversion rates at the end of the chemotherapy in the drug_susceptible group(91 cases)and the drug_resistant group(31 cases)were 85 7% and 67 7%,respectively.Conclusions If the drug_resistance,particularly for multidrug_resistant,occurred in recurrent cases during retreatment,the therapeutic efficacy is less satisfactory than that in the drug_susceptible cases.It is important to control the infectious source of new treated cases actively and reduce occurrence of drug_resistant cases for tuberculosis control project.