急性心肌梗死病人红细胞膜及血浆唾液酸的改变

THE CHANGES OF ERYTHROCYTE MEMBRANE AND PLASMA SIALIC ACID IN THE PATIENTS WITH ACUTE MYOCARDIAL INFARCTION

①目的 探讨急性心肌梗死（ Ａ Ｍ Ｉ）病人红细胞膜唾液酸（ Ｒ Ｂ Ｃｍ  Ｓ Ａ）和血浆唾液酸（ Ｐ Ｓ Ａ）的变化及意义。②方法 采用 Ｂｉａｌｓｃｈｅ 试剂法检测 Ｒ Ｂ Ｃｍ  Ｓ Ａ 含量， Ｆ８８３６ 化学比色法检测 Ｐ Ｓ Ａ 含量。③结果 Ａ Ｍ Ｉ病人 Ｒ Ｂ Ｃｍ  Ｓ Ａ 含量低于正常对照组，而 Ｐ Ｓ Ａ 含量则高于正常对照组，差异有极显著性（ｔ＝ ４．４１，４．８５， Ｐ＜ ０．０１）。两组 Ｒ Ｂ Ｃｍ  Ｓ Ａ 与 Ｐ Ｓ Ａ 皆呈负相关（ｒ＝ － ０．４８６，－ ０．５０３， Ｐ＜ ０．０５）。④结论 Ａ Ｍ Ｉ病人 Ｓ Ａ 的代谢发生障碍。检测 Ｒ Ｂ Ｃｍ  Ｓ Ａ 和 Ｐ Ｓ Ａ 含量对 Ａ Ｍ Ｉ诊断有一定价值。

Objective\ To study the changes and the significance of red blood cell membrane sialic acid (RBCm SA) and plasma sialic acid (P SA)in the patients with acute myocardial infarction (AMI).\ Methods\ RBCm SA was determined with bialsche reagent test and P SA was estimated with F 8836 chemical colorimetric method.\ Results\ RBCm SA in the patients with AMI was significantly lower than that in the control group, but P SA in the patient group was significantly higher than that in the normal control group, so there was a striking difference( t=4.41,4.85,P <0.01). Negative correlations were found between RBCm SA and P SA ( r=-0.486,-0.503, P <0.05) in both normal control group and the patients group.\ Conclusion\ The metabolic disturbance of SA happens to the patients with AMI. Detecting RBCm SA and P SA surely has diagnosis value.\;