甘露醇对犬氟康唑药代动力学的影响

Influence of mannitol on the pharmacokinetics of fluconazole in dogs

目的：研究甘露醇与氟康唑合用对氟康唑药代动力学的影响．方法：采用 Ｈ Ｐ Ｌ Ｃ法测定６ 条杂种犬的血药浓度，３ Ｐ８７药代动力学软件拟合药时曲线。结果和结论：测得单用及合用时氟康唑的主要药代动力学参数ｋａ 分别为（０．１９±０．０８）和（ ０．４０±０．１３）ｈ－ １ （ Ｐ＜ ０．０５），ｔ１／２ｋａ分别为（３．９７± １．２１）和（２．０５±１．０８）ｈ（ Ｐ＜ ０．０５），而ｃｍ ａｘ 和 Ａ Ｕ Ｃ两组无明显差异 Ｐ＞０．０５）

Objective: To study the influence of mannitol on the pharmacokinetics of fluconazole. Methods:After oral administration the concentration of fluconazole in serum was determined by HPLC. The concentration of fluconazole in serum time profiles were conformed by 3P87 program. Results and conclusion: The pharmacokinetic parameters of fluconazole alone and combined with mannitol were: k a=(0.19±0.08) and (0.40±0.13) h -1 ( P <0.05), t 1/2 k a =( 3.97±1.21) and (2.05±1.08) h ( P < 0.05 ). No significant differences were noted between fluconazole alone and in combination with mannitol in c max and AUC ( P >0.05).