摘要
目的观察瑞波西汀与文拉法辛治疗难治性抑郁症患者的疗效及对生存质量的影响。方法将80例难治性抑郁症患者平均分为研究组(瑞波西汀)和对照组(文拉法辛),在治疗前和治疗后1、2、4、6周末分别用汉密尔顿抑郁量表(HAMD)、总体疗效量表(CGI)和副反应量表(TESS)评定疗效和副作用。结果治疗1周后研究组HAMD总分及各因子分比治疗前明显降低(P<0.01),且治疗因子分显著低于对照组(P<0.05)。文拉法辛组副作用比瑞波西汀组多。结论瑞波西汀治疗难治性抑郁症疗效确切。
Objective To investigate the influence of Reboxetine and venlafaxine in treatment-refractory depression.Methods Being used the vendom control study.80 treatment-redfractory depression were divided into study group（Reboxetine） and control group（venlafaxine）.Effects and side effects were assessed with HAMD and CGI and TESS respectively,WHOQ0L-BREF instruments were used to evaluate the patients quality of life before and after drug abministration,by menas of analyzing the scores in every domains.before and after 1、2、4、6 months treatment.Results compared with before treatment,the todal scores of HAMD and the scores of every factor were signficantly decreased after 1-month treatment with study group and the score of treatment factors was significantly lower than that of contrast group（P0.01）,the tess scores of study group were lower than that of contrast group（P0.01）.The side effects were more in venlafaxine group those in Reboxetine group.Conclusion The study suggests that Reboxetine is effective in the treatment of treatmene-refractory depression.
出处
《中国中医药现代远程教育》
2011年第8期151-152,共2页
Chinese Medicine Modern Distance Education of China
