妊高征患者脐血、羊水中降钙素基因相关肽含量的变化

The changes of calcitonin gene related peptide levels in cord plasma and amniotic fluid of pregnancy induced hypertention patients

目的：探讨妊娠高血压综合征（妊高征）患者脐血、羊水中降钙素基因相关肽（ Ｃ Ｇ Ｒ Ｐ）含量的变化。方法：应用放射免疫测定法，观察２６ 例正常妊娠妇女和 ３２ 例妊高征患者脐血与羊水中 Ｃ Ｇ Ｒ Ｐ含量的变化。结果：脐动脉血中 Ｃ Ｇ Ｒ Ｐ含量，妊高征患者显著高于正常妊娠者（ Ｐ＜ ０．０５），且随着病情的加重逐渐增加，重度者显著高于轻度者（ Ｐ＜ ０．０５）；羊水中 Ｃ Ｇ Ｒ Ｐ含量妊高征患者显著高于正常妊娠对照组（ Ｐ＜ ０．０５）；脐动脉血、羊水中 Ｃ Ｇ Ｒ Ｐ含量的变化与新生儿 １ ｍ ｉｎ Ａｐｇａｒ 评分呈显著负相关（ Ｐ＜ ００１， Ｐ＜ ０．０５）。结论：脐动脉血、羊水中 Ｃ Ｇ Ｒ Ｐ含量的变化可能与胎儿宫内缺氧有关。

Objective:To determine calcitonin gene related peptide (CGRP) levels in cord plasma and amniotic fluid of pregnancy induced hypertension (PIH) patients. Methods: CGRP levels in cord plasma and amniotic fluid of 26 normal pregnant women (NP group) were measured with radioimmunoassay (RIA).Results: Plasma CGRP levels in umbilical artery of PIH patients were significantly higher than that of NP women ( P <0.01),and it increased as the disease became worse, the severe increased markedly when compared with the mild ( P <0.05).CGRP levels in amniotic fluid of PIH patients were significantly higher than that of NP women( P <0.05).There was a negative correlation between neonatal 1 min Apgar Scores after delivery and CGRP levels in umbilical artery( P <0.01),as well as that in amniotic fluid( P <0.05).Conclusion: The changes of CGRP levels in umbilical artery and amniotic fluid are correlated with intrauterine fetal distress