肺心病患者血中一氧化氮和内皮素-1检测分析

ANALYSIS ON BLOOD NITRIC OXIDE AND ENDOTHELIN1 IN CHRONIC COR PULMONALE

目的：探讨一氧化氮（ＮＯ）与内皮素－１（ＥＴ－１）在肺心病患者急性期血中含量变化的临床意义。方法：慢性肺心病急性发作期患者３０例，健康对照组２６例，分别采用放射免疫分析法和分光比色法测定血中ＥＴ－１和ＮＯ含量。结果：肺心病组ＥＴ－１和ＮＯ分别为（６４．９±２９．２）ｎｇ／Ｌ和（５．２±２．１）μｍｏｌ／Ｌ，对照组ＥＴ－１和ＮＯ分别为（４９．１±４．１）ｎｇ／Ｌ和（４．５±１．０）μｍｏｌ／Ｌ，肺心病组与对照组比，ＥＴ－１显著升高（Ｐ＜０．０１），ＮＯ升高不明显（Ｐ＞０．０５）。结论：ＮＯ含量不高，可能是肺心病长期慢性肺部疾病上皮细胞和内皮细胞受损严重，已不能产生足够的ＮＯ来拮抗ＥＴ－１，持续高ＥＴ－１在肺心病的病理生理过程中起重要作用。

Objective: To investigate the clinic value in the blood nitric oxide (NO) and endothelin1 (ET1) in the chronic cor pulmonale Methods: 30 cases with chronic cor pulmonale of acute course were compared to 26 cases in normal condition as controlsThe content in blood ET1 and NO were tested by the radioimmunoassay and spectrophotometry Results: The contents of blood ET1 and NO in the chronic cor pulmonale were (649292)ng/L and (5221)mol/L,while those in the control group were (49141)ng/L and (4510)mol/LCompared to the control group,the content of blood ET1 was larger than the normal (P<001);the content of blood NO was normal (P>005) Conclusion: Because of the epithelioid cells and endotheliocyte being injured seriously in the chronic cor pulmonale,there was not enough NO to antagonize the ET1,but the content of blood NO remain normalThe lasting high content in the blood ET1 plays an important,role in the chronic cor pulmonale\=