摘要
目的:探讨POEMS综合征的临床特征和诊断治疗。方法:对16例POEMS综合征患者临床资料、相关检查及治疗方法进行回顾性研究。结果:主要临床特征包括多发性周围神经病、脏器肿大,内分泌改变,单克隆浆细胞异常,皮肤改变,骨破坏,水肿是POEMS的主要表现。激素联合免疫抑制剂对部分病人有效。结论:POEMS综合征是一种少见的多脏器损害疾病,诊断较难。周围神经炎、下肢水肿是POEMS综合征常见的早期临床特征。
Objective：To evaluate the clinical features and therapies of POEMS syndrome.Methods：The clinical materials of 9 patients with POEMS syndrome were analyzed retrospectively.Results：The major clinical features are shown as follow：Polyneuropathy,Organomegaly,Endocrinopathy,Monoclonal gammopathy,and Skin changes.bone lesion and anemia.patients can benefit from the treatment of methylprednisolone and immunosuppressant.Conclusion：POEMS syndrome was a rare disease with multi organ involvement.which made its diagnosis difficult.Polyneuropathy,edema of lower extremity are the common early symptoms of POEMS syndrome.
