狼疮性肾炎尿NAG活性的改变及其临床意义

CHANGE OF URINARY NAG IN LUPUS NEPHRITIS AND ITS CLINICAL SIGNIFICANCE

目的 :探讨尿 N-乙酰 - β- D-氨基葡萄糖苷酶 ( NAG)活性在狼疮性肾炎 ( L N)患者的改变及其临床意义。方法 :对 10 0例正常人和 3 0例狼疮性肾炎 ( L N)患者进行血肌酐及尿 NAG活性测定。用生化法测定血肌酐 ,用硝基苯酚比色法测定尿NAG。结果 :L N患者在肾功能正常时 NAG活性较正常对照组明显增高 ( P<0 .0 1) ;L N患者在肾功能不全时 NAG活性较肾功能正常时明显增高 ( P <0 .0 5 ) ;血肌酐及尿 NAG活性的直线相关分析表明两者不相关 ( P >0 .0 5 )。结论 :L N患者肾小管间质损害在肾功能正常时已经发生 ,且随肾小球病变的加重 。

Objective:To study the change of the urinary N acetyl β D glucosaminidase (NAG) activities in the lupus nephritis (LN) patients and its clinical significance Methods:Serum creatinine and urinary NAG activity measurement were performed in 30 LN patients and 100 controls Urinary NAG activities were measured by nitrophenol colorimetric analysis technique Results:Urinary NAG activities in renal sufficiency patients were significantly higher than those of controls;urinary NAG activities in renal insufficiency group of LN patients were significantly higher than those in renal sufficiency group There were no significant correlation between urinary NAG activities and the serum creatinine Conclusion:The change of urinary NAG in the lupus nephritis patients suggested that the damage in renal tubular interstitium had taken place in LN patients when they were in the renal sufficiency stage;With the development of the lesion in the glomerular, the degree of renal tubal interstitium damage in LN also increased