应用CD_3AK细胞预防肝癌术后复发的初步观察

THE EFFECTS OF CD 3AK CELLS THERAPY ON POSTOPERATIVE RECURRENT RATE OF HEPATOCELLULAR CARCINOMA (HCC)

目的：观察ＣＤ３ＡＫ细胞治疗对肝癌术后复发的影响。方法：６２例肝癌切除术按序号单双数的原则分为两组，研究组３２例术后１周开始应用ＣＤ３ＡＫ细胞治疗，每隔２～３个月施行一疗程，共２～６个疗程；对照组３０例术后不用ＣＤ３ＡＫ细胞治疗，仅作一般护肝治疗。结果：①研究组术后１年复发率为６．３％（２／３２）明显低于对照组２６．７％（８／３０）（Ｐ＜０．０５）；②研究组和对照组术后４周免疫功能测定有明显差异（Ｐ＜０．０５）。结论：术后应用ＣＤ３ＡＫ细胞对预防肝癌复发是一个有效的方法。

Objective : To observe the effects of CD 3AK cells therapy on postoperative recurrent rate of HCC Methods :62 cases with HCC were divided into two groups,and the experimental group of 32 cases with HCC were treated by CD 3AK cells after hepatic resection The control group of 30 cases with HCC were treated only by hepatic resection Result : The 1 year recurrent rate of experimental group ( 6 3% ) was significantly lower than that of control group (26 7%) Conclusion :The result indicated that CD 3AK cells therapy for HCC is an approach to prevent recurrence after hepatic resection