影响口腔鳞状细胞癌患者预后的临床病理因素分析

Clinical Pathology and Prognostic Factors in Oral Squamous Cell Carcinoma

目的:研究影响口腔鳞状细胞癌(Oral squamous cellcar cinoma,OSCC)术后患者预后的临床病理因素。方法:回顾性研究55例手术治疗的原发口腔鳞状细胞癌患者与预后相关的因素:年龄、性别、发病部位、颈部淋巴结转移情况、肿瘤细胞分化程度等。结果:平均发病年龄为57.35±12.02岁,牙龈鳞癌的复发转移率最高(45.5%),舌部第二(44%),颊部第三(37.5%),唇癌预后最好(0.0%)。术前颈部淋巴结转移情况、肿瘤细胞分化程度与预后有关。肿瘤细胞的分化程度与术前淋巴结转移无显著相关性。术前有颈部淋巴结转移合并中低分化与预后差相关。结论:口腔鳞状细胞癌的预后与发病部位无显著相关性。肿瘤中低分化及术前有淋巴结转移者易出现术后复发转移。

Objective： The study goal was to determine which clinical features correlated with prognosis in patients surgically treated for oral squamous cell carcinoma （OSCC）. Methods： The records of 55 OSCC patients surgically treated were reviewed retrospec- tively. Their prognosis in relation to age, gender, tumor site, neck lymph node involvement, differentiation were analyzed. Results： The mean age is 57.35±12.02 years. Tumor recurrence or neck nodal metastasis occurred frequently at gingiva （in 45.5 % of cases）, followed by tongue （44%）, buccal mucosa （37.5%）, and lip （0.0%）. The nodal involvement, cell differentiation significantly affected the prognosis （P 0.05, x2 test）. Tumor cell differentiation was no correlated with lymph node metastasis. Combined neck nodal metastasis and poor differentiation was associated with poor clinical outcome （P0.05）. Conclusions： We conclude that site had little influence on prognosis. Neck lymph nodal metastasis and poor differentiation are significant prognostic factor of oral squamous cell carcinoma.