丙型肝炎病毒感染与肝细胞癌相关关系的研究进展

Relationship Between HCV Infection and Hepatocarcinoma

世界上有数亿的人口患有丙型肝炎,而丙型肝炎病毒(HCV)的感染易转为慢性,引起肝细胞炎性坏死及再生,导致肝纤维化、硬化甚至肝细胞癌(HCC),是危害人类健康的一个重要卫生问题。HCV的感染可导致HCC的发生,但HCV相关性HCC的发生机制尚不清楚。免疫逃避机制是感染慢性化的一个重要原因,病毒通过其基因组编码的蛋白使肝细胞发生转化,可能是肝细胞癌变的重要机制。

There is hundreds of millions of population in the world suffering from hepatitis C,and this is an important health problem to human. Hepatitis C virus（HCV） infection prone to chronic inflammation, and cause injury, necrosis and regeneration, leading to liver fibrosisand even hepatocellular carcinoma（HCC）.HCV infection can lead to the occurrence of HCC,butHCV-relatedpathogenesis of HCC has been in the study. Immune escape mechanism is an important reason for chronic infection, and the virus proteins may be the im- portant mechanism for malignant transformation.