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胆道梗阻后肝脏自由基损伤及粉防己碱保护作用的实验研究 被引量:2

Experimental study on hepatic free radical injury and the protective effects of tetrandrine after biliary obstruction
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摘要 目的 观察胆道梗阻后肝脏的自由基损伤和粉防己碱( Tet) 的保护作用。方法 复制大鼠胆道梗阻模型,每日给予 Tet 30 mg/kg 体重灌胃,动态观测肝组织丙二醛( M D A) 和超氧化物歧化酶( S O D) 含量及血清 T Bil、 A L T、 A L P、 G G T 含量。结果 胆道梗阻后,血清 T Bil、 A L T、 A L P、 G G T 水平逐渐升高,肝组织 M D A 含量逐渐升高, S O D 逐渐减少,各梗阻组与对照组比较, P< 0 .05 。各 Tet 治疗组与同时相梗阻组比较,血清 T Bil、 A L T、 A L P、 G G T 水平下降( P< 0 .05) ;肝组织 M D A 含量减少( P<0 .01) , S O D 含量升高( P< 0 .05) 。肝组织 M D A 含量与血清 A L T、 A L P 含量变化呈明显正相关,r 值分别为0 .949 和0 .843( P< 0 .01) 。结论 自由基损伤可能是胆道梗阻导致肝损害的重要机制之一, Tet对胆道梗阻所致肝损害有明显保护作用。 Objective\ To investigate hepatic free radical injury and the protective effects of tetrandrine (Tet) after biliary obstruction.Method\ The Tet was given to the rat once a day by gavage at a dose of 30 mg/kg. The contents of liver malondialdyhyde (MDA) and superoxide dismutase (SOD), the levels of serum T Bil, ALT, ALP and GGT were determined in each group. Results\ After CBO, serum T Bil, ALT, ALP and GGT levels and liver MDA were increased significantly, while SOD decreased markedly, as compared with control group ( P <0.05). As compared with CBO group at the same obstructed phase, serum T Bil, ALT, ALP and GGT levels and liver MDA in Tet treated groups were decreased significantly ( P <0.05), while liver SOD increased ( P <0.05). The liver MDA content was highly positively correlated with serum ALT and ALP levels ( P <0.01).Conclusion\ Liver free radical injury may be one of the important mechanisms of hepatic injury induced by biliary obstruction. Tet can protect liver effectively from the injury after biliary obstruction.\;
出处 《中华实验外科杂志》 CAS CSCD 北大核心 1999年第5期406-407,共2页 Chinese Journal of Experimental Surgery
关键词 胆道梗阻 肝脏损伤 自由基损伤 粉防己碱 Biliary obstruction\ \ Liver\ \ Free radical\ \ Tetrandrine
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参考文献2

  • 1张永刚,国外医学.病理生理与临床分册,1997年,17卷,255页
  • 2张永刚,国外医学.中医中药分册,1997年,19卷,6页

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