正常青春前期、青春后期儿童血中Leptin水平与生长激素结合蛋白关系的研究

Relationship between serum leptin levels and serum growth hormone binding protein in normal prepubertal and postpubertal children

目的研究Ｌｅｐｔｉｎ与营养、生长的关系。方法对４９例正常青春前期及４８例正常青春后期儿童进行身高、体重测量及血Ｌｅｐｔｉｎ、生长激素结合蛋白（ＧＨＢＰ）检测。结果正常青春前期儿童血Ｌｅｐｔｉｎ水平在女孩（４９１±２７９）μｇ／Ｌ，较男孩（３７１±３５５）μｇ／Ｌ略高，但无显著性差异（Ｐ＞００５）；在青春后期女孩（１２７９±７７２）μｇ／Ｌ，较男孩（４３４±３２５）μｇ／Ｌ显著升高（Ｐ＜００１）。无论青春前期还是青春后期男、女孩血中Ｌｅｐｔｉｎ水平均与ＧＨＢＰ、体重指数（ＢＭＩ）显著相关。结论Ｌｅｐｔｉｎ很可能是一种营养与生长间的调节因子并且可能具有多种功能。

Objective To study the relationship of leptin,growth and nutrition. Methods Serum levels of leptin, serum growth hormone binding protein(GHBP), height and weight were observed in 49 normal prepubertal children and 48 normal postpubertal children.Results The serum levels of leptin in female were higher than that in male in normal postpubertal children[(12 79±7 72)μg/L vs (4 34±3 25)μg/L, P <0 01], but they were not significantly different between female and male in normal prepubertal children[(4 91±2 79)μg/L vs (3 71±3 55)μg/L, P >0 05]; both prepubertal and postpubertal children's serum levels of leptin were positively correlated to GHBP and body mass index . Conclusion The leptin may be a regulative factor in the nutrition and growth, the physiological functions of leptin are various as well.