维生素D受体基因Taq Ⅰ位点多态性与亚洲男性前列腺癌易感性的Meta分析

Polymorphism of vitamin D receptor gene Taq Ⅰ and genetic susceptibility to prostate cancer in Asian man:a meta-analysis

目的探讨维生素D受体（VDR）基因Taq Ⅰ位点多态性与亚洲男性前列腺癌易感性的关系。方法检索PubMed、中国知网、万方数据库、维普中文科技期刊,获取VDR基因Taq I位点多态性与亚洲男性前列腺癌易感性的病例-对照研究。以前列腺癌组与对照组人群基因型分布的OR值为效应指标,采用固定或随机效应模型进行合并分析,并进行偏倚评估,应用STATA10.0软件进行统计学处理。结果共纳入文献10篇,研究10项,累计前列腺癌病例1 141例,对照1 685例。与等位基因T相比,C等位基因合并的OR（95%CI）为0.81（0.70~0.94）;与野生基因型TT相比,CT和CC＋CT基因型合并的OR（95%CI）分别为0.86（0.74~1.01）和0.84（0.73~0.97）。结论 VDR基因Taq Ⅰ位点变异可能会降低亚洲男性个体患前列腺癌的危险性。

Objective To investigate the relationship between the polymorphism of vitamin D receptor（VDR） gene Taq Ⅰ and genetic susceptibility to prostate cancer in Asian man.Methods PubMed,China National Knowledge Infrastructure（CNKI）,Wanfang database and Weipu database were searched for published case-control studies investigating the association between VDR Taq Ⅰ polymorphism and susceptibility to prostate cancer in Asian man.The odds ratio was calculated to evaluate the genotypes of patients with prostate cancer and controls.Fixed or random effect models were selected for pooled odds ratio calculation.Publication bias was assessed.All statistical analysis was conducted with Stata10.0 software.Results A total of ten case-control studies involving 1,141 prostate cancer patients and 1,685 controls were analyzed in our study.Compared with the T allele,the pooled odds ratio（OR） [and 95% confidence interval（CI）] for C allele was 0.81（0.70~0.94）;compared with the wide-type genotype（homozygote TT）,the pooled OR（95% CI） for CT and CC＋CT genotypes were 0.86（0.74~1.01） and 0.84（0.73~0.97）,respectively.Conclusions Polymorphism of VDR Taq Ⅰ may reduce risk of prostate cancer in Asian man.