采用阿司匹林、维生素C联合治疗精液液化异常65例临床分析

Efficacy of combined Aspirin and vitamin C treatment in men with semen non-liquefaction

目的探讨精液液化异常的治疗方案。方法对65例精液液化异常患者采用阿司匹林(0.1,3次/d)、维生素C(0.1,3次/d)联合治疗,治疗时间2月。采用CASA检测精液。结果治疗前(组1)、治疗后1月(组2)、治疗后2月(组3)、停药1月(组4)后,各种参数分别为:体积[(3.03±0.77)、(3.09±0.78)、(3.11±0.86)、(2.96±0.65)]mL;精子密度[(43.98±49.69)、(41.46±35.77)、(42.09±43.34)、(38.94±35.62)]×106/mL,A级精子活动度[(9.42±5.60)、(11.95±5.14)、(13.52±4.92)、(14.17±5.37)]%,B级精子活动度[(11.85±8.72)、(15.45±7.08)、(17.20±7.87)、(21.77±8.74)]%,C级精子活动度[(26.18±16.50)、(31.23±14.05)、(29.97±14.80)、(28.63±12.26)]%,D级精子活动度[(52.55±21.60)、(41.37±15.48)、(39.31±17.12)、(35.43±15.61)]%,精液液化时间分别为60、(37.09±10.38)、(32.78±8.18)、(32.58±9.03)min。A、B、D级精子活动度、精液液化时间组间具有统计学差异(P<0.01)。LSD-t检验显示,液化时间、A、B、D级精子活动度组1与其他3组间均存在统计学差异(P<0.01)。结论阿司匹林和维生素C联合应用可以降低精液液化时间,有助于改善精子活动度,可以用于治疗精液液化异常。

Objective To assess the efficacy of combined Aspirin and vitamin C treatment in men with semen non-liquefaction.Methods Combined treatment of Aspirin（0.1,3t/d） and vitamin C（0.1,3t/d） was administered for 2 months to 65 men with semen non-liquefaction.The semen volume,density,liquefaction time and motility before treatment,one month after treatment,two months after treatment,and one month after medication were observed and compared.Results The semen volume and density showed no difference,while seminal liquefaction time was shortened and motility increased with treatment time.Conclusions Combined use of Aspirin and vitamin C can improve the semen liquefaction and increase seminal motility.