介入治疗前后局部晚期宫颈癌细胞中N-cadherin、E-cadherin的表达及其意义

N-cadherin and E-cadherin expressions and significance before and after interventional treatment for locally advanced cervical cancer cells

目的检测介入治疗前、后局部晚期宫颈癌细胞中黏附分子N-cadherin、E-cadherin表达的变化,评价其对肿瘤转移和浸润的影响。方法采用免疫组织化学染色(SP)方法,检测14例介入治疗前后局部晚期宫颈癌患者癌细胞中E-cadherin和N-cadherin的表达情况。结果介入治疗前E-cadherin在局部晚期宫颈癌细胞中的阳性表达率为62.5%,N-cadherin的阳性表达率为100%。介入治疗后E-cadherin的阳性表达率增至100%,但表达增加无统计学意义(P>0.05);N-cadherin的阳性表达率下降为71.4%,表达下降有统计学意义(P<0.05)。结论介入治疗能够降低肿瘤细胞的间质表型分子N-cadherin的表达,有可能促进上皮表型分子标志物的正常表达,从而降低肿瘤的侵袭及浸润行为。

Objective To investigate the expressions of adhesion molecules E-cadherin and N-cadherin before and after interventional treatment for locally advanced cervical cancer cells and and thus evaluate its effect on tumor metastasis and infiltration.Methods Immunohistochemistry（SP） was used to detect E-cadherin and N-cadherin expressions in 14 cases before and after interventional therapy in patients with locally advanced cervical cancer.Results E-cadherin in locally advanced cervical cancer cells had positive or weakly positive expression with the expression rate of 62.5%.N-cadherin expression was 100%.After interventional treatment,the E-cadherin positive expression rate increased to 100%,but the change was not significant（P〉0.05）.N-cadherin positive expression decreased to 71.4% with a significant change（P〈0.05）.Conclusion Interventional treatment can reduce tumor cell mesenchymal phenotype（N-cadherin） expression,which may promote the epithelial phenotype of the normal expression of molecular markers and then reduce the invasion and infiltration of tumor behavior