急性肾小球肾炎和紫癜性肾炎患儿外周血单个核细胞IL-13变化的临床意义

Changes and Clinical Significance of Interleukin 13 in Peripheral Blood Mononuclear Cells from Children with Acute Glomerulonephritis or Henoch Schonlein Purpura Nephritis

目的 观察白细胞介素 13 (IL- 13 )在急性肾小球肾炎 (AGN)和紫癜性肾炎 (HSPN)患儿中的变化 ,并探讨其临床意义。方法 应用 EL ISA法检测 2 4例 AGN和 2 0例 HSPN患儿外周血单个核细胞 (PBMC)培养上清中 IL - 13的水平。结果 AGN急性期和 HSPN活动期 PBMC培养上清中 IL - 13水平显著高于恢复期和正常对照组 ,恢复期降至正常水平。结论 IL - 13在 AGN和 HSPN发病机制中发挥着一定的作用。 PBMC培养上清中 IL -

Objective The purpose of this study was to investigate the changes and clinical significance of interleukin (IL) 13 in the patients with acute glomerulonephritis (AGN) or Henoch Schonlein purpura nephritis (HSPN). Methods The production of IL 13 was determined by ELISA in peripheral blood mononuclear cells (PBMC) in 24 children with AGN and 20 children with HSPN during their acute symptomatologic phase and remission stage. Results The production of IL 13 was significantly increased in patients with AGN or HSPN in acute symptomatologic phase compared with controls, while in remission stage the amouts of IL 13 decreased to normal levels. Conclusion The results suggested that IL 13 was involved in the pathogenesis of AGN and HSPN.The expression of IL 13 in PBMC can be served as a marker to predict the activation of AGN and HSPN.