重型脑外伤患者血浆抵抗素水平动态变化与预后的关系

Dynamic Changes of Plasma Resistin Level in Patients with Serious Traumatic Brain Injury and Its Association with Prognosis

目的:研究血浆抵抗素水平与重型脑外伤预后的相关性。方法:取80例重型脑外伤患者在入院时及入院后第1、2、3、5、7天静脉血,另取80例体检健康者静脉血做对照。用ELISA法测定血浆抵抗素浓度,分析血浆抵抗素水平与格拉斯哥(GCS)评分及死亡的相关性,以及抵抗素水平对重型脑外伤患者1个月内死亡的预测特异度和敏感度。结果:脑外伤后第1、2、3、5、7天血浆抵抗素水平明显增高。入院时血浆抵抗素水平增高是脑外伤1个月内死亡的危险因素(P=0.042),与入院时GCS评分呈显著负相关(P<0.001),对脑外伤后患者1个月内死亡有显著预测价值(P<0.001)。结论:脑外伤后血浆抵抗素水平显著增高,可作为重型脑外伤患者预后判断的重要指标。

Aim： To determine the correlation of plasma resistin level with disease outcome in patients with serious traumatic brain injury （TBI）. Methods： Venous blood was obtained from 80 cases on admission at day 1, 2, 3, 5, and 7 after TBI. Plasma resistin concentration was measured by enzyme-linked immunosorbent assay. Venous blood from 80 healthy people was also measured as control. Results： After TBI, plasma resistin level increased significantly. Plasma resistin level on admission was an independent predictor for 1-month mortality （P=0.042）, and was negatively associated with Glasgow coma scale score （P0.001）, and predicted 1-month mortality of patients with the high value. Conclusion： Plasma resistin level increased significantly after TBI, maybe as an important predictor for clinical outcome.