人工饲养条件下死亡恒河猴肺脏病理改变分析

Analysis on Pathology of Lung Lesion in Captive Rhesus Monkey

目的观察人工饲养条件下实验恒河猴肺脏病理改变,探讨实验猴呼吸系统疾病分布规律和病理改变特点,丰富实验猴自发病变基本研究资料。方法对1998～2008年云南地区饲养的自然死亡的155只恒河猴(年龄2～20岁)的肺脏进行病理检查,按年龄分为幼年组、成年组、老年组,并对观察结果进行统计学分析。结果实验猴肺脏主要病变有大叶性肺炎、支气管肺炎、间质性肺炎、肺气肿、支气管扩张症、胸膜炎、肺肉芽肿性炎等12种,出现率最高的为支气管肺炎(18.71%)和大叶性肺炎(16.74%)。恒河猴肺脏病变在不同年龄阶段均有发生,老年猴组肺脏病变发生率最高,疾病类型和发生率在不同年组中分布不相同,统计学分析显示:支气管炎病变成年组发病率明显高于幼年组;肺气肿病变老年组明显高于成年组和幼年组,(P<0.05)。结论人工饲养条件下死亡实验猴肺脏病变检出率较高,实验猴肺脏病变在不同年龄阶段存在差异,实验猴肺脏病理改变结果丰富了实验猴的基本研究资料,对实验猴的质量控制和相关动物实验有重要价值。

Objective To observe the pathology changes in lungs lesions of captive rhesus monkey,explore the distribution rule and pathological features of diseases in respiratory system.Methods We postmortem 155 nature dead monkeys from 2 ～ 20 years which were bred in institutes in Yunnan provinces.Monkeys were divided into young,adult and aged groups according to their age.The pathology changes of lung were investigated by routine histopathological technique and the analysis of chi-square test was performed.Results Of 155 monkeys,59 samples have lung lesions,the ratio was 38.06%.the main lesion include pulmonary edema,intralveolar hemorrhage,lobar pneumonia,alveolar organization,lobular pneumonia,chronic bronchitis,bronchiectasis,interstitial pneumonia,granulomatosis of lung,emphysema,pulmonary abscess,pleurisy.The kinds and the frequency of lesions are different in different age groups.Conclusions The incidence rates of diseases of lung of breeding rhesus macaques is higher and its interference effect should be seriouslytaken.Some pathological changes of lung are different in diverse age groups.The results of our test enrich the data of thecaptive monkeys,and it is useful in quality control of captive monkeys and animal tests.