白介素家族细胞因子与干细胞动员被引量：19

Interleukin Family Cytokines and Stem Cell Mobilization

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摘要干细胞移植将成为或已经成为治疗多种疾病的一种重要方法,干细胞移植的成功率与干细胞增殖及扩增后干细胞的归巢能力密切相关,其过程受到许多细胞因子的调控。目前的研究发现白介素家族中的细胞因子IL1、IL2、IL3、IL4、IL6、IL7、IL8、IL9、IL10、IL11、IL12在干细胞动员过程中起到非常重要的调节作用。本文综述了这部分白介素家族成员的生物活性特征及其对干细胞动员的作用。 Stem cell transplantation will be or have become an important method of treatmenting various diseases.The success rate of stem cell transplantation is closely related to the stem cell proliferation and amplified,the process of stem cell transplantation is regulating by many cytokines.The current studies found that the cytokines of interleukin family IL1,IL2,IL3,IL4,IL6,IL7,IL8,IL9,IL10,IL11,IL12 play a very important role in the process of regulating the stem cell mobilization.This review summary the biological activities and the their effect on the stem cell mobilization of this part of the interleukin family menbers.

作者杨青张连峰

机构地区中国医学科学院

出处《中国比较医学杂志》 CAS 2011年第5期62-65,共4页 Chinese Journal of Comparative Medicine

基金卫生部行业基金实验动物和人类疾病动物模型资源扩展(200802036) 十一五新药专项支持(2009ZX09501-026)

关键词白介素家族细胞因子干细胞动员 Interleukin family Cytokines Stem cell mobilization

分类号 R34 [医药卫生—基础医学] R332 [医药卫生—人体生理学]

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1Lord PCW,Wilomth LMG,Mizel SB,et al.Expression of interleukin-1 alpha and beta genes by human blood polymorphonuclear leukocytes[J].JClin.Invest.1991,87:1312-1321.
2Yonemura Y,Ku H,Hirayama F,et al.Interkeukin 3 or interleukin 1 abrogates the reconstituting ability of hematopoietic stem cells[J].Proc Natl Acad Sci USA,1996,93:4040 -4044.
3Zsebo KM,Yuschenkoff VN,Schiffer S,et al.Vascular endothelial cells and granulopoiesis:interleukin-1 stimulates release of G-CSF and GM-CSF[J].Blood,1988,71:99-103.
4Wright DE,Bowman EP,Wagers AJ,et al.Hematopoietic stem cells are uniquely selective in their migratory response to chemokines[J].J Exp Med,2002,195:1145 -1154.
5Schaafsma MR,Fibbe WE,Vander HD,et al.Increased numbers of circulating haematopoietic progenitor cells after treatment with highdose interleukin22 cancer patients[J].Br J Haematol,1990,76 (2):180-185.
6Yee CC,Gabriela R,Leah FS,et al.Interleukin-2 and granulocyte-macrophage-colony-stimulating factor immunomodulation with high-dose chemotherapy and autologous hematopoietic stem cell transplantation for patients with metastatic breast cancer[J].J Hematol 2009,90:627-634 DOI 10.1007/sl2185-009-0439-6.
7Lonial S,Hicks M,Rosenthal H,Langston A,Redei I and Torre C,et al.A randomized trial comparing the combination of granulocyte-macrophage colony-stimulating factor plus granulocyte colony-stimulating factor versus granulocyte colony-stimulating factor for mobilization of dendritic cell subsets in hematopoietic progenitor cell products,Biol Blood Harrow Transplant 2004 (10),848-857.
8Ballestrero A,Ferrando F,Garuti A,Basta P,Gonella R and Stura P,et al.Comparative effects of there cytokine regimens after high-dose cyclophosphamide:granulocyte colony-stimulating factor,granulocyte-macrophage colony-stimulating factor (GM-CSF),and sequential interleukin-3 and GM-CSF[J].J Clin Oncol 1999 (17),1296.
9Octavio RC,Jorge VO,Ruben LS,et al.Granulocyte Colony-Stimulating Factor Produces a Decrease in IFNc and Increase in IL-4 when Administrated to Healthy Donors[J].Journal of Clinical Apheresis 2010,25:181-187.
10Kollet O,Shivtiel S,Chen YQ,et al.HGF,SDF-1,and MMP-9 are involved in stress-induced human CD34 + stem cell recruitment to the liverf J].J Chin Invest 2003,112:160-169.