轻度认知功能障碍患者视觉注意的事件相关电位研究

Study of event-related potentials on mild cognitive impairment patients＇ visual attention

目的探讨轻度认知功能障碍（MCI）患者的视觉注意功能。方法采用基本认知能力测验和事件相关电位（ERPs）技术——视觉Oddball试验对16例老年MCI患者（MCI组）和17名年龄匹配的正常老年人（对照组）进行测试，对基本认知能力测验结果、ERPs的行为数据、P3b（选择性注意）和P3a（非选择性注意）的波幅和潜伏期进行比较。结果MCI组的无意义图形再认和双字词再认成绩明显低于对照组，差异有统计学意义（P〈0．05）；MCI组的正确率明显低于对照组，反应时明显长于对照组，差异均有统计学意义（P〈0．01）；MCI组P3a波幅明显低于对照组，P3b潜伏期明显短于对照组，差异有统计学意义（P〈0．01）；MCI组和对照组无意义图形再认正确数均与P3a波幅相关（P〈0．01）。结论MCI患者的非选择性注意功能下降，选择性注意反应速度减慢。

Objective To explore the visual attention of mild cognitive impairment patients. Methods Basic cognitive ability test and oddball task event-related potentials（ ERPs）were used to measure the visual attention of 16 mild cognitive impairment subjects （MCI group）and 17 health older adults （control group）. Results came from Basic cognitive ability test,data of ERPs beheavior and the amplitude and latency of P3a（ related to nonvoluntary attention） and P3b（ related to voluntary attention）of the two said groups were compared and contrasted. Result The results of meaningless figures recognition and two-word recogniton of MCI group were lower than NC group significantly （ P 〈 0.05 ）. The correct rate of MCI group was were lower than control group significantly（ P 〈 0.01 ）. The reaction time of MCI group was were longer than control group significantly（P 〈 0.01 ）. The amplitude of P3a was lower than the health control （ P 〈 0.01 ） significantly. The latency of P3b was significantly prolonged compared to the control （ P 〈 0.01 ）. The correct number of meaningless figures recognition of MCI group and control group were respectively corrected with the amplitude of P3a of the groups （ MCI group R = 0. 83, P 〈 0.0l ; control group R = 0.86, P 〈 0.01 ）. Conclusions The mild cognitive impairment patients had deficit on non-selective attention function. The selectiv attention function of MCI group was slower compared to eonntrols.