慢性盆腔炎动物模型子宫病理学改变与血流变学关系

Relationship between blood rheology and pathological histology of chronic pelvic inflammatory disease of rats model

目的探讨慢性盆腔炎(chronic pelvic inflammatory disease,CPID)动物模型子宫病理学改变与其血液流变学之间的关系。方法用混合菌接种法诱导大鼠CPID动物模型,其中假手术组仅打开腹腔,不注射混合菌,光镜下观察大鼠子宫的病理改变,并以"锥板法"检测血液流变学各项指标。结果 CPID大鼠模型病理学显示慢性炎症改变,血液流变学各项指标显著升高(P<0.01)。结论 CPID动物模型子宫病理学改变与血流变学各项指标的升高关系密切。

Purpose To explore the relationship between the blood rheology and pathological histology of chronic pelvic inflammatory disease of rats model.Methods Injected mixed bacteria into two sides of the uterus to induce CPID models,control group was reserved as comparision of fake operation by just openning their abdomens without injecting mixed bacteria,the pathological histology of uterus was observed and the blood rheology was measured by Cone Plate method.Results The model group＇ pathological histology showed chronic inflammatory changes,and the data of the blood rheology was significantly increased（P0.01）.Conclusion The pathological change in chronic pelvic inflammatory disease has a close relationship with the increase of the indicators of blood rheology.