维甲酸防治增殖性玻璃体视网膜病变的实验研究

An experimental study of the effect of retinoic acid on proliferative vitreoretinopathy

为探讨维甲酸对实验性增殖性玻璃体视网膜病变的防治作用及维甲酸对视网膜是否有毒性，本实验将２６只色兔随机分成４组，对照组Ａ组２０眼、Ｃ组６眼，玻璃体内注射ＰＢＳ，实验组Ｂ组２０眼、Ｄ组６眼，玻璃体内注射１５ｕｇ／ｍｌ维甲酸，Ａ组和Ｂ组玻璃体内同时注射２...

To evaluate the effect of retinoic acid(RA) on an experimenntal model of proliferative vitreoretinopathy(PVR),and the toxicity of RA on the retinal tissue.26 pigmented rabbits were divided into 4 groups at random.In control A group(20 eyes)and C group(6 eyes),PBS was injected intravitreally.B group(20 eyes)and D group(6 eyes),15 ug/ml RA was injected 2 5×10 5 retinal pigment epithelium(RPE)cells were injected in A and B groups.The eyes were examined by ophthalmology,PVR grades were observed.The retinas of the enucleated eyes on the 28th day were examined by light microscopy annd transmission electron microscopy.After 4 weeks,the rate of tractional retinal detachment(TRD) was significantly lower in amimals that received 15 ug/ml RA than in the controls.No evidence of toxicity was found in retinas after intravitreal injection of 15 ug/ml RA.There was no toxic effect on the retinas and the occurence of TRD was inhibited effectively by using 15 ug/ml RA.RA dissolved in ethnol could be useful to treat PVR when silicon oil is unnecessary.