PRK与LASIK治疗高度近视的实验研究

Histopathological comparison of photorefractive keratectomy and laser in situ keratomileusis in rabbits

研究ＰＲＫ与ＬＡＳＩＫ治疗兔眼高度近视的组织病理学损害。方法：对十只新西兰大白兔右眼行ＰＲＫ，左眼行ＬＡＳＩＫ，手术范围－１０．０Ｄ，分别于术后十天、一月、三月、半年随机选取动物摘除双眼，行光镜及电镜检查。结果：ＰＲＫ术后角膜上皮、上皮基底膜、前弹力层、浅层基质发生了损伤，故引起了不同程度的组织病理学损害，一至三月时最为明显，半年时减轻。ＬＡＳＩＫ术后，角膜细胞正常，胶原纤维规则排列，组织病理学损害较轻。结论：ＰＲＫ与ＬＡＳＩＫ矫正高度近视均不会造成长期的组织病理学损害，但从组织学比较而言。

Objective:To investigate the histopathological comparison of photorefractive keratectomy and laser in situ keratomileusis in rabbits.Method:We treated 10 New Zealand white rabbits with PRK(right eye),and LASIK(left eye),both treated with -10 0D. After surgery 10 days,one month,three month,half year,all eyes removed and prepared for light and electron microscopy.Results:All histological investigations after PRK showed an obvious anterior stromal,epithelial cell layer,the epithelial basal membrane disorganization after PRK 1～3 months,and have a light chang at half year.After LASIK showed a regular epithelial and stromal architecture.Conclusion:Though both PRK and LASIK dont have a long term histopathological damage,Lasik appears especially suitable for correcting higher myopic.