新型三氮唑类化合物的抗念珠菌属真菌的活性

Antifungal activity of new triazole compounds against candida species

目的：研究一类新型的三氮唑化合物对念珠菌属真菌的抗真菌活性。方法：采用体外抗真菌活性试验， 测定化合物的最低抑菌浓度（ Ｍ Ｉ Ｃ），从而评价化合物的生物活性作用。结果：所有２４ 个新的化合物对念珠菌属真菌均有不同的抑制作用，其中对白念珠菌的活性最好。化合物 １２ 对白念珠菌的活性最强，是标准对照品氟康唑的２５６ 倍。化合物１７ 对耐氟康唑的白念珠菌的活性最强，是标准对照品氟康唑的１６ 倍。结论：化合物 １２ 和１７ 可以作为两个潜在的药物进一步进行研究。

Objective: To study the antifungal activity of the new triazole compounds against candida species . Methods: The MICs of new triazole compounds were determined in in vitro antifungal tests to evaluate the activities of title compounds. Results: All new triazole compounds had activity against candida species , especially high activity against candida albicans . Compound 12 exhibited remarkably high efficacy and was 256 times more active than fluconazole against candida albicans . Compound 17 was the most effective agent against fluconazole resistant candida albicans and was 16 times more active than fluconazole. Conclusion: The 2 compounds are worth advanced studying as potential drugs.