硬膜外腔内注入新斯的明术后镇痛效果的观察

Observation on the Postoperative Analgesic Effect by Epidural Neostigmine after Surgery

目的：评价新斯的明用于硬膜外腔的术后镇痛效果。方法：随机将４５ 例接受剖宫产术的病人分为 ３组，每组１５ 例，于手术结束时分别一次性硬膜外腔内注入生理盐水８ ｍ ｌ；新斯的明１ ｍ ｇ；新斯的明 １ ｍ ｇ＋ 氟哌利哆１．５ ｍ ｇ。分别记录术后镇痛强度、镇痛时间和发生副反应的例数，并与生理盐水对照组作对比。结果：新斯的明１ｍ ｇ 的镇痛强度与镇痛时间和生理盐水对照组相比有显著性差异（ Ｐ＜ ０．０１），在合用氟哌利哆１．５ ｍ ｇ 后新斯的明的副反应发生例数减少。结论：硬膜外腔内注入新斯的明＋ 氟哌利哆混合液可作为一种方法用于术后镇痛。

Objective: The purpose of the present study was to evaluate the effect of epidural neostigmine for the relief of pain in patients after surgery. Methods: 45 parturients who were scheduled for cesarean delivery during epidural anesthesia were divided randomly into three groups. The numbers of each group were fifteen. At the end of surgery parturients were injected by saline 8ml, 1mg neostigmine and 1mg neostigmine plus 1.5mg droperdol respectively into epidural space. The analgesic time, patients's pain score were recorded and compared with that of saline control group. Results: neostigmine can prolong analgesic time and have an effect of analgesia, which were significantly different from control group (P< 0.01). Combined epidural neostigmine and droperdol can reduce adverse effects of neostigmine. Conclusions: Neostigmine plus droperdol may be clinically useful for postoperative analgesia.