培哚普利对心肌梗死患者心肌重构的影响

Effects of perindopril on myocardial remodeling after myocardial infarction in patients

目的:探讨培哚普利对心肌梗死患者心肌重构的影响。方法:将100例心肌梗死患者随机分为治疗组和对照组各50例,2组患者均给予常规治疗,治疗组加用培垛普利(4mg.d-1),并于治疗前和治疗1年后比较二者左室短轴缩短率(FS)、左室重量指数(LMVI)、舒张早期与舒张晚期充盈速度比值(E/A),并对患者的心功能进行NYHA评级,观察药物的不良反应,统计因心衰入院率及死亡率。结果:1年后治疗组患者FS、LMVI、E/A、心功能、血压、心衰入院率和死亡率均好于对照组,差异有显著性(P<0.05)。结论:培哚普利阻抑左室重构过程,改善左室功能,效果更好,值得临床推广应用。

AKSTRACT：OBJECTIVE To explore the effects of perindopril on myocardial remodeling after myocardial infarction in patients. METHODS 100 cases with recent acute myocardial infarction （AMI） were randomly divided into the treatment group （50 cases） and the control group （50 cases） ;All patients received conventional therapy, the treatment group were plus treated with perindopril（4 mg. d^-1 1 ） for 12 months. The FS.LMVI.E/A and NYHA classification in all patients of two groups were observed and compared, the ad- verse effects, heart failure hospitalization rate and mortality were observed in all patients. RESULTS At t-year after treatments, the FS, LMVI, E/A, NYHA classification, heart failure hospitalization rate and mortality in treatment group were better than that in control group, there were significant difference（P〈0. 05）. Cl）NCLUSION Perindopril can prohibit progressive left ventricular remode-ling, improve the left ventricular function after myocardial infarction in patient, so perindopril is worthy of being recommended in clinical practice.