袖状胃切除术对糖代谢的影响

Influence of sleeve gastrectomy on glycometabolism

目的:通过建立几种不同袖状胃切除模型,探讨袖状胃切除术对糖代谢的影响。方法:分别在肥胖诱导大鼠(F组)、糖尿病GK鼠(D组)、普通Wistar大鼠(C组)建立袖状胃切除模型,术后连续观察8周,比较3组术后体重、摄食和外周血活性Ghrelin、GLP-1、胰岛素及血糖浓度的变化。结果:与C组相比,F组大鼠与D组大鼠体重下降且摄食量减少,血糖改善(P<0.05),F组大鼠与D组大鼠外周血活性Ghrelin浓度下降,GLP-1浓度升高(P<0.05)。结论:袖状胃切除术在肥胖及2型糖尿病大鼠模型上能有效改善糖代谢。

Objective To explore the effect of sleeve gastrectomy （SG） on glycometabolism with several experimental metabolic models. Methods Obesity rats induced by high-fat diet （F group）, GK rats （G group） and Non-obese Wistar rats （control group） were underwent SG and the variation of weight reduction, foodintake, plasama ghrelin, insulin, GLP-I, glycemia were compared in three groups. Results Compared with control group, F and D groups showed effective weight loss and anorexic effects, improvent in glycemia with increased insuli level during eight weeks postsurgery （P 〈 0.05）, The F and D groups exhibited significantly decreased levels of plasma ghrelin and elevated levels of plasma GLP-1 （P 〈 0.05）. Conclusion SG was represented an effective way of improvement glycometabolism and lipid metabolism on several experimental metabolic models.