食管鳞状细胞癌中SFRP1、Wnt-1的表达及临床意义

Expression and clinical significance of SFRP1 and Wnt-1 in esophageal squamous cell carcinoma

目的:研究分泌型卷曲相关蛋白1(SFRP1)和Wnt-1在食管鳞癌中的表达情况,探讨其在食管鳞状细胞癌发生发展及与临床病理特征的关系。方法:应用免疫组织化学法(SP法),检测60例食管鳞状细胞癌组织和40例正常食管黏膜中SFRP1和Wnt-1蛋白的表达。结果:食管鳞状细胞癌中SFRP1的阳性表达率为25.0%,显著低于癌旁正常组织黏膜中的92.5%(χ2=43.81),Wnt-1在食管鳞状细胞癌中的阳性表达率为73.3%,显著高于癌旁正常组织中的17.5%(χ2=29.94)。在食管鳞癌组织中,SFRP1的表达与临床病理因素无相关性,Wnt-1的表达与组织分化程度有关。结论:SFRP1和Wnt-1在食管鳞癌的发生、发展中起一定的作用,它们有望成为辅助参考指标应用于临床,并可能为食管鳞癌的生物治疗和预后判断提供部分理论依据。

Objective To investigate the expressions of SFRPland Wnt-1 in the esophageal squamous cell carcinomma（ESCC） and approach the relationship between the genes and clinical pathology and the roles in the process of esophageal squamoas cell carcinogenesis. Methods Immunohistochemistry was used to detect the expressions of SFRP1 and Wnt-1 in 60 cases of ESCC and 40 cases of normal esophageal tissue. Results （1） The positive rate of SFRP1 expression in cancerous tissue （25%） was significantly lower than that in normal esophageal tissue （92.5%）, （~2 = 43.81）. The positive rate of Wnt-1 in cancerous tissue （73.3%） was significantly higher than that in normal esophageal tissue（17.5%）（~2 = 29.94）. （2）In ESCC, the positive expression rate of SFRP1 was not associated with clinical pathology, the positive expression rate of Wnt-1 was associated with tumor differentiation. Conclusion SFRP1 and Wnt-1 take part in the carcinogenesis and progression of ESCC. They could be regarded as clinical assistant reference markers and offer some evidence for biotherapy and prognosis of ESCC.