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帕瑞昔布对神经外科经蝶入路术后疼痛和机体应激相关细胞因子的影响 被引量：8

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摘要 目的:观察帕瑞昔布对经蝶入路术后机体应激相关细胞因子和术后疼痛的影响。方法:经蝶入路手术患者90例,分为超前镇痛组、术后镇痛组和对照组,比较给药前后各组ET-1、TNF-α、IL-6变化,VAS疼痛评分,术后曲马多使用人次数。结果:对照组术后ET-1、TNF-α、IL-6水平较术前显著升高(P<0.05),VAS评分较其他两组高(P<0.05);术后曲马多使用人次数对照组高于其他两组(P<0.05)。结论:帕瑞昔布能明显缓解围手术期的过度应激反应,有效减轻神经外科术后疼痛。
作者 马薇涛 李红英 于卫 赵国栋
机构地区 广东省医学科学院广东省人民医院麻醉科
出处 《实用医学杂志》 CAS 北大核心 2011年第11期2034-2036,共3页 The Journal of Practical Medicine
关键词 帕瑞昔布 ET-1 TNF-α IL-6 超前镇痛
分类号 R614 [医药卫生—麻醉学]
  • 相关文献

参考文献7

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二级参考文献14

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共引文献67

同被引文献76

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引证文献8

二级引证文献44

实用医学杂志
2011年 第11期

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