摘要
目的:探讨胰岛素对新诊断2型糖尿病患者胰岛B细胞的保护作用。方法:将86例新诊断2型糖尿病患者随机分为观察组和对照组,观察组患者应用胰岛素治疗,对照组患者采用口服降糖药治疗。在所有患者血糖达标并稳定2个月后,比较2组患者血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL);胰岛B细胞功能指标胰岛素分泌指数(Homa-β)、胰岛素抵抗指数(Homa-IR)、C肽葡糖糖负荷曲线下面积(AUCcp)、胰岛素早相分泌功能指数(IG30)及氧化应激指标活性氧活力(ROS)、丙二醛(MDA)、还原型谷胱甘肽(GSH)、超氧化物歧化酶(SOD)。结果:2组患者血糖达标且无显著性差异时,治疗组患者TG、TC、LDL均明显低于对照组,差异有统计学意义(P<0.05或P<0.01);治疗组Homa-IR较对照组下降(P<0.05),Homa-β、AUCcp、IG30均高于对照组(P<0.01);治疗组ROS、MDA明显低于对照组,GSH、SOD均高于对照组(P<0.01)。结论:2型糖尿病患者早期应用胰岛素强化控制血糖,可有效改善体内代谢异常,改善胰岛B细胞功能和体内的氧化应激状态。
OBJECTIVE: To investigate the protective effects of insulin on islet B cells in newly diagnosed type 2 diabetes mellitus patients. METHODS: 86 patients with newly diagnosed type 2 diabetes were randomly assigned into observation group and control group. Observation group received insulin therapy while control group was given oral dose. 2 month after fulfilled and stable blood glucose control, TC, TG, LDL, HDL , Homa-β, Homa-IR, AUCcp, IG30, and oxidative stress indicators ROS, MDA, GSH, SOD were detected and compared between 2 groups. RESULTS: There was no significant difference between 2 groups after fulfilled blood glucose control. TG, TC, LDL of treatment group were significantly lower than those of control group, there were significant difference (P0.05 or P0.01); Homa-IR of treatment group decreased, compared with control group (P0.05). Homa-β, AUCcp and IG30 of treatment group were higher than those of control group (P0.01); ROS and MDA of treatment group were significantly lower than those of control group, GSH and SOD of treatment group were those of control group (P0.01). CONCLUSION: For the newly diagnosed type 2 diabetic patients, early use of intensive therapy of insulin for blood glucose control not only improve the body metabolism and protect the islet B cells function, but also make oxidative stress better.
出处
《中国药房》
CAS
CSCD
北大核心
2011年第24期2233-2235,共3页
China Pharmacy
关键词
新诊断2型糖尿病
胰岛素
口服降糖药
胰岛B细胞
氧化应激
Newly diagnosed type 2 diabetes mellitus
Insulin
Oral antidiabetic drug
Islet B cells
Oxidative stress