还原型谷胱甘肽对慢性阻塞性肺疾病急性发作期患者血气指标的影响

Effects of Reduced Glutathione on Blood Gas Indexes in Patients with Chronic Obstructive Pulmonary Disease

目的:探讨还原型谷胱甘肽对慢性阻塞性肺疾病(COPD)急性加重期患者血气指标的影响。方法:将40例符合入选标准的COPD急性发作期患者,随机均分为治疗组和对照组,治疗组患者除给予常规治疗外,加用注射用还原型谷胱甘肽2.4g·d-1,加入到5%葡萄糖溶液250mL中静脉滴注,qd,连用10d;对照组仅给予常规治疗。观察治疗前后2组患者动脉血气指标、6min步行试验及主观感觉的变化。结果:治疗10d后,2组患者动脉血氧分压(PaO2)均较治疗前有显著提高,动脉血二氧化碳分压(PaCO2)均较治疗前显著降低(P<0.05),且2组间PaO2、PaCO2改善情况比较,差异均有统计学意义(P<0.05),治疗组显著优于对照组。结论:COPD患者体内存在氧化-抗氧化失衡,治疗中加用还原型谷胱甘肽可对抗机体氧化损伤,改善患者缺氧状况。

OBJECTIVE： To explore the improvement effect of reduced glutathione on hypoxemia in patients with chronic obstructive pulmonary disease （COPD） in acute exacerbations period. METHODS： 40 COPD patients in acute exacerbations period were included and randomly divided into treatment group （20 cases） and control group （20 cases）. Treatment group additionally received reduced glutathione 2.4 g·d-1, adding into 5% glucose solution 250 mL, iv. gtt, qd for 10 days besides conventional therapy. Control group received conventional therapy alone. The changes of arterial blood gas, 6-min walking test and subjective feeling 2 groups were observed. RESULTS： After 10 days treatment, the level of PaO2 in 2 groups increased significantly while the level of PaCO2 decrease （P0.05）. And there was statistically difference in PaO2 and PaCO2 between 2 groups （P0.05）. Treatment group was significantly better than the control group. CONCLUSION： Oxidant-antioxidant imbalance is found in COPD patient, and additional therapy of reduced glutathione can fight against the oxidative damage and improve anoxic condition.