美托洛尔联合稳心颗粒治疗室性期前收缩的临床观察

Clinical Observation of Betaloc Combined with Wenxin Granule in the Treatment of Premature Ventricular Beats

目的:观察美托洛尔联合稳心颗粒治疗室性期前收缩的有效性及安全性。方法:将2008年9月-2010年3月在我市3家"三甲"医院收治的室性期前收缩患者随机分为治疗组和对照组,治疗组60例采用美托洛尔联合稳心颗粒(美托洛尔12.5～25mg,bid,口服;稳心颗粒每次1袋(9g),tid,冲服),对照组58例单用美托洛尔治疗(用法同治疗组),2组疗程均为4周。结果:治疗4周后,在室性期前收缩疗效方面,治疗组总有效率为93.3%,对照组为72.4%,2组比较差异有统计学意义(P<0.01);治疗组心电图改善总有效率为91.67%,明显优于对照组(67.24%,P<0.01);治疗组生活质量改善明显优于对照组(P<0.05);2组心率变异(HRV)改善,但无明显差别(P>0.05)。2组均未见严重不良反应。结论:美托洛尔联合稳心颗粒治疗室性期前收缩疗效明显优于单用美托洛尔,并能在一定程度上改善患者的生活质量。

OBJECTIVE： To observe the effectiveness and safety of betaloc combined with Wenxin granules in the treatment of premature ventricular beats. METHODS： Chose Sep. 2008-Mar. 2010 premature ventricular beats pationts of cless these grade A hospitals of our city, all patients were divided into 2 groups. 60 cases in treatment group were treated with betaloc and Wenxin granules （metoprolol 12.5～25 mg, bid, p.o.; Wenxin granules, 1 bag （9 g） each times, tid）. 58 cases in control group were treated with betaloc alone （at the same dose as those in treatment group）. The therapeutic course lasted for 4 weeks. RESULTS： After 4-week treatment, the total effective rate for premature ventricular beats in treatment group was 93.3%, and that was 72.4% in control group. There was significant difference between 2 groups （P0.01）. The total effective rate for ECG in treatment group was 91.67%, which was significantly higher than in control group （67.24%, P0.01）. The improvement of quality of life in treatment group was superior to those in control group （P0.05）. HRV become well after therapy. There was no significant difference between 2 groups （P0.05）. There were no serious adverse reactions in 2 groups. CONCLUSION： Betaloc combined with Wenxin granules is superior to betaloc alone in the treatment of premature ventricular beats and also improves the quality of life to some extent.