胺碘酮治疗老年室性心律失常的疗效观察

Efficacy Observation of Amiodarone in the Treatment of Ventricular Arrhythmias in Old Patients

目的:观察胺碘酮治疗老年室性心律失常的临床疗效。方法:将我院2009年6月-2010年6月收治的94例室性心律失常患者随机均分为2组,对照组采用强心、利尿、扩血管、心肌细胞营养剂等综合治疗,观察组在对照组基础上加用胺碘酮治疗,观察2组的临床疗效及对心率和PR间期的影响。结果:观察组的室性心律失常改善总有效率(83.0%)和心功能改善总有效率(76.6%)均明显高于对照组(63.8%,55.3%)(P<0.05)。观察组治疗后心率明显下降,与治疗前比较差异有统计学意义(P<0.05),但对照组治疗前、后心率比较,差异无统计学意义(P>0.05),并且观察组治疗后心率明显低于同期对照组,2组比较差异有统计学意义(P<0.05)。2组治疗后PR间期均有所延长,但差异无统计学意义(P>0.05)。2组均未见严重不良反应发生。结论:胺碘酮治疗老年室性心律失常能够明显提高心律失常改善率和心功能改善率,并且能够显著降低心率。

OBJECTIVE： To observe the clinical efficacy of amiodarone in the treatment of ventricular arrhythmias in old patients. METHODS： From Jun. 2009 to Jun. 2010, 94 cases of ventricular arrhythmias were randomly divided into 2 groups. Control group with 47 cases was given normal therapy and observation group with 47 cases was treated with amiodarone on the basis of normal therapy. The clinical efficacy, heart rate, and PR interval were compared between 2 groups. RESULTS： The total effective rates of ventricular arrhythmias improvement and heart function improvement in observation group were significantly higher than that in control group（83.0% vs. 63.8%, 76.6% vs. 55.3%, P0.05）. Compared with pre-treatment, heart rate were significantly decreased（P0.05）after treatment in observation group while there was no significant difference in control group（P0.05）. Moreover, the level of heart rate in observation group were significantly lower than in control group, there was significant difference between 2 groups（P0.05）. PR interval was prolonged, there was no significant difference in 2 groups before and after treatment（P0.05）. There were no serious ADR in 2 groups. CONCLUSION： Amiodarone can improve the improvement rate of ventricular arrhythmias and heart function in old patients with ventricular arrhythmias, and decrease the heart rate significantly.