还原型谷胱甘肽联合丹参治疗酒精性肝病的疗效观察

Efficacy Observation of Reduced Glutathione Combined with Salvia miltiorrhiza for Alcoholic Liver Disease

目的:观察还原型谷胱甘肽联合丹参治疗酒精性肝病的疗效。方法:将50例酒精性肝病患者随机均分为2组,对照组25例,给予门冬氨酸钾镁、甘草酸二铵和维生素C静脉滴注;治疗组在对照组基础上加用谷胱甘肽1200mg和复方丹参注射液20mL,qd,静脉滴注。2组疗程均为1个月。监测治疗前、后肝功能的变化。结果:治疗组在肝功能改善方面明显优于对照组(P<0.05);治疗组和对照组总有效率分别为92.0%和68.0%,2组比较有显著性差异(P<0.05)。结论:还原型谷胱甘肽联合丹参治疗酒精性肝病确有良好疗效。

OBJECTIVE： To observe the clinical efficacy of reduced glutathione combined with Salvia miltiorrhiza for alcoholic liver disease. METHODS： 50 patients with alcoholic liver disease were randomly divided into 2 groups. 25 patients in control group received intravenous infusion of potassium magnessium aspartata and diammonium glycyrrhizinate and vitamin C continuously. Trial group were given reduced glutathione 1 200 mg and S. miltiorrhiza 20 mL once a day. The treatment period of 2 groups lasted for one month. The changes of liver function were monitored before and after treatment. RESULTS： The improvement of liver function in trial group was better than control group significantly（P0.05）. Total effective rate of 2 groups were 92.0% and 68.0% respectively. There were significant differences（P0.05）. CONCLUSION： Reduced glutathione combined with S. miltiorrhiza for alcoholic liver disease shows satisfactory effect.