静脉应用胺碘酮治疗心房颤动复律的疗效观察

Efficacy Observation of Amiodarone in the Treatment of Atrial Fibrillation Cardioversion with Intravenous Administration

目的:观察静脉应用胺碘酮对心房颤动复律的临床疗效。方法:将172例心房颤动患者随机分为胺碘酮组和安慰剂组。胺碘酮组(n=87)静脉推注胺碘酮5mg·kg-1,再以胺碘酮10～20mg·kg-1·d-1加入0.9%氯化钠注射液中持续静脉滴注,维持直至恢复为窦性节律;安慰剂组(n=85)静脉推注和静脉滴注0.9%氯化钠注射液,并给予控制心室率治疗。观察2组复律成功率和复律时间。结果:胺碘酮组有74例(85.1%)恢复为窦性节律,安慰剂组有68例(80.0%)恢复为窦性节律,2组比较差异无统计学意义(P>0.05)。胺碘酮组心房颤动持续时间短于安慰剂组(P<0.01)。胺碘酮组1例患者出现窦性心动过缓,停药后恢复。结论:胺碘酮静脉应用不能提高复律率,但能缩短心房颤动持续时间。

OBJECTIVE： To observe clinical efficacy of amiodarone in the treatment of atrial fibrillation cardioversion with intravenous administration. METHODS： 172 patients with atrial fibrillation were randomly divided into amiodarone group and placebo group. Amiodarone group （n=87） received amiodarone 5 mg·kg-1 intravenously, and then followed by continuous infusion of 0.9% Sodium chloride injection with amiodarone at 10～20 mg·kg-1·d-1 until sinus rhythm was restored. Placebo group （n=85） received 0.9% Sodium chloride injection with intravenous push and intravenous infusion, and ventricular rate control treatment. Successful rate and time of rhythm control of 2 groups were observed. RESULTS： 74 patients （85.1%） in amiodarone group returned into sinus rhythm. 68 patients （80.0%） in placebo group also returned into sinus rhythm （P0.05）. The duration of atrial fibrillation in amiodarone group was shorter than in placebo group （P0.01）. One patient suffered from sinus bradycardia in amiodarone group. CONCLUSION： Intravenous administration of amiodarone can not improve the successful rate of rhythm control but can shorten the duration of atrial fibrillation.