摘要
针对RhuschalconeⅠ的结构特征,将其切为2个合成片断:化合物8和化合物10,然后将2个片断连接。以间苯二酚和对羟基苯甲醛为起始原料,经选择性甲基化、碘代、甲氧甲基化、羟醛缩合、Ullmann反应和脱保护等步骤,完成了RhuschalconeⅠ的合成。关键中间体与最终产物的化学结构经1H NMR、13C NMR和ESI-MS等表征及分析予以确认。
Rhuschalcone Ⅰ was adopted to two synthetic fragments,compound 8 and compound 10,then the two fragments were combined together.Rhuschalcone Ⅰ were first synthesized by selective methylation,iodination,methoxymethylation,aldol condensation,Ullmann reaction,deprotection from m-dihydroxybenzene and p-hydroxybenzaldehyde.The chemical structures of the key intermediate and the final target product were verified by 1H NMR,13C NMR and ESI-MS.
出处
《应用化学》
CAS
CSCD
北大核心
2011年第6期652-656,共5页
Chinese Journal of Applied Chemistry
基金
甘肃省自然科学基金(3ZS062-B25-017)资助项目
