丝裂霉素缓释剂局部植入药代动力学的实验研究

Pharmacokineties of mitomycin Cof sustained release pellet by local embedding

目的 研究丝裂霉素缓释剂（ Ｍ Ｍ Ｃ Ｓ Ｒ Ｐ） 在大鼠和狗体内的药代动力学。方法 用高效液相色谱法（ Ｈ Ｐ Ｌ Ｃ） 测定血浆丝裂霉素 Ｃ（ Ｍ Ｍ Ｃ） 的浓度。结果 大鼠皮下植入 Ｍ Ｍ Ｃ Ｓ Ｒ Ｐ 后， Ｍ Ｍ Ｃ 可持续、缓慢释放；犬肌肉植入０４ ｍｇ·ｋｇ－ １ Ｍ Ｍ Ｃ Ｓ Ｒ Ｐ 后，其有效血浆浓度曲线呈一室模型特点，其维持有效血浆浓度时间（００１ ｍｇ· Ｌ－ １） 为２４０ ｈ ，其峰值浓度仅为ｉｖ 同剂量 Ｍ Ｍ Ｃ 的２７ ％ 。结论 Ｍ Ｍ Ｃ Ｓ Ｒ Ｐ 有显著的缓释作用。

Objective To study the pharmacokinetics of mitom ycin Cofsustained release Pellet ( M M C S R P) inrats and dogs. Methods The concentration of M M Cin plasma was measured by H P L C. Results M M Ccouldbe released slowly and last after subcutaneous em bedding of M M C S R Pin rats ; After intram uscular embedding(im ) of M M C S R P in dogs, the plasma durg concentration time curve showed the characteristies of onecom partment model. The time of effective plasma concentration (0 01 mg · L- 1 ) was 240 h . The peakconcentration of im M M C S R P was 27 % of that of iv same dose M M C. Conclusion M M C S R P possessessignificant sustained release effect.