芪加合剂对Lewis肺癌小鼠细胞免疫功能的影响

Effect of Qijaheji on the cellim m une functionin mice with Lewis lung carcinoma

目的 研究芪加合剂对ｌｅｗｉｓ 肺癌小鼠免疫功能的影响。方法 检测 Ｃｏｎ Ａ 和 Ｌ Ｐ Ｓ 诱导的小鼠脾淋巴细胞增殖反应和 Ｉ Ｌ１ 、 Ｉ Ｌ２ 产生的水平。结果 芪加合剂（１３７５ ～２７５ ｇ·ｋｇ － １） 可使荷癌小鼠低下的 Ｔ、 Ｂ 淋巴细胞增殖反应，脾细胞产生 Ｉ Ｌ２ 恢复至接近正常水平，还可促进荷癌小鼠腹腔巨噬细胞产生 Ｉ Ｌ２ 。结论 芪加合剂抑制肿瘤作用可能与其提高荷瘤小鼠细胞免疫功能有关。

Objective To investigate the effect of Qijaheji on the cell im mune function in mice with lungcarcinoma . Methods The proliferative reaction of spleen lymphocytes in mice induced by Con A and L P Sandthe production of I L 1 and I L 2 were determined . Results Qijaheji 13 75 ～27 5 g·kg - 1 ,ig ×7 days or 15days markedly increased the level of the proliferative reaction ofly mphocytesinduced dy Con Aof L P Sand I L 2produced by spleen cells in mice with Lewis lung carcino ma . The Qijaheji also enhanced the content of I L 1produced by peritoneal macrophage . Conclusion Inhibition of Qijaheji on Lewis lung carcinoma in mice maybe related to the im provement of the im m une function .