急性冠脉综合症合并糖尿病患者冠脉病变严重程度与P选择素水平变化的临床观察研究

A Clinical Observation of Severity of Coronary Artery Lesion and Changes of P selectin in Patients with Acute Coronary Syndrome Combined with Diabetes Mellitus

目的探讨P选择素与急性冠脉综合征合并糖尿病患者冠脉病变严重程度的相关性。方法检测48例急性冠脉综合征合并糖尿病(ACS合并糖尿病组)患者,40例急性冠脉综合征(单纯ACS组)患者,30例健康对照组血清P选择素水平;研究冠状动脉病变支数、左主干病变、冠脉Gensini评分与P选择素水平的相关性。结果 ACS合并糖尿病组、单纯ACS组P选择素水平、冠脉Gensini评分显著高于正常对照组(P<0.01),ACS合并糖尿病P选择素水平、冠脉Gensini评分显著高于单纯ACS组(P<0.01)。与冠状动脉1支病变和2支病变组比较,3支病变或左主干病变患者P选择素水平显著升高,差异有统计学意义(P<0.01)。结论急性冠脉综合征合并糖尿病患者P选择素水平明显升高,和冠状动脉病变程度之间存在相关性。

Objective To investigate the correlation of P selectin and severity of coronary artery lesion in patients with acute coronary syndrome （ACS） combined with diabetes mellitus （DM）, Methods The levels of serum P selectin were measured in 48 patients with acute coronary syndrome combined with diabetes mellitus （ACS ＋DM group）, 40 patients with acute coronary syndrome （ACS group）, and 30 controls. The numbers of impaired coronary artery, left main coronary stenosis, Gensini scoring of coronary stenosis and the levels of serum P selectin were compared respectively. Results The level of P selectin and Gensini scoring of coronary stenosis in ACS＋DM group were significantly higher than those in the ACS group and in controls （all P〈0.01）, and the level of P selectin and the Gensini score were higher in ACS group than in the controls （P〈O.O1）. There were obvious positive correlations in the levels of serum P selectin with impaired coronary arteries, left main coronary stenosis, and Gensini score （P〈0.O1）. Conclusion Serum level of P selectin correlates with coronary artery stenosis in patients with acute coronary syndrome combined with DM. It is an important clinical parameter to reflect the severity of myocardial necrosis.