肠非霍奇金淋巴瘤20例临床病理学研究

A clinicopathological analysis of 20 cases intestinal Non-Hodgkin's lymphoma

目的研究原发性肠非霍奇金淋巴瘤的病理形态及临床特点，分析其临床误诊原因。方法回顾分析２０例原发性肠非霍奇金淋巴瘤的临床资料，并行常规病理学检查及部分免疫组织化学染色。结果本组中男１３例，女７例。平均年龄３７．９岁，２０－４０岁者占５０％，发病部位以结肠和盲肠居多，术前仅３例得以确诊。病理分类Ｔ细胞性６例，Ｂ细胞性１４例，其中２例为肠病相关性Ｔ细胞性淋巴瘤，４例为粘膜相关性Ｂ细胞性淋巴瘤。结论原发性肠淋巴瘤临床误诊率极高，肠镜检查及准确地活检有利于本病术前确诊。

Objective To study the pathological and clinical features of intestinal Non-Hodgkin 's lymphoma and analyze thecauses of its misdiagnosis. Methods 20 patients with primary intestinal Non-Hodgkin's lymphoma (INHL) in the period of1994~1997 were reviewed retrospectively. Routine pathological examination and special immunohistochemical stainings were used in the study. Results 20 cases of INHL, consisting of 13 male and 7 female cases, 50% cases were in 20-40 years (mean,37.9 years). INHL occurred frequently in colon and appendix; before the operation, only in 3 cases, the diagnosis was defi nite. 6 cases were T-cell lymphoma, 14 cases were B-cell lymphoma, of which 2 cases were enteropathy-associated T-cell lym- phoma and 4 cases were mucosa-associated B-cell lymphoma. Conclusions The results showed that rate of INHL misdiagnosisis quite high. The enteroscopy and correct biopsy can provide iportant evidences in histoghopathological diagnosis of INHL.