腹膜透析患者神经-肌肉反应时间及其影响因素的探讨

Reaction time and its influencing factors in peritoneal dialysis patients

目的探讨腹膜透析患者神经-肌肉反应时间及其影响因素。方法采取横断面研究,选取2010年8月至11月在北京大学第三医院透析中心复诊的103例患者为研究对象,测定患者的神经-肌肉反应时间和握力,并收集一般资料、临床生化指标和透析充分性指标等。组间比较使用方差分析,通过简单相关及多元线性回归分析探讨透析患者反应时间(reaction timeRT)及其影响因素。结果快反应组28例:RT≤0.63s;中反应组50例:0.63s<RT≤0.87s;慢反应组25例:RT>0.87s。多元回归分析显示,患者的年龄、受教育程度、握力和心脑血管疾病是影响腹膜透析患者神经-肌肉反应时间的独立因素(adjR2=0.326,P<0.05)。结论腹膜透析患者反应时间较慢。除年龄和受教育程度外,患者的营养状态及心脑血管合并症是影响腹膜透析患者神经肌肉反应时间的独立因素。

Objective To investigate the possible factors affecting the reaction time （RT） in continuous ambulatory peritoneal dialysis （CAPD） patients. Methods A total of 103 CAPD patients from a single center were enrolled in this cross-sectional study. RT in CAPD patients was measured by a standard method, and their clinical data were also collected. Data comparison between groups was performed using one-way ANOVA. Simple correlation analysis and multiple linear regression analysis were used to explore the relationship between RT and other factors in CAPD patients. Results RT was longer in CAPD patients than in healthy people. Multiple linear regression analysis showed that age （P =0.049）, education level （P =0.008）, handgrip strength （P =0.011） and history of cardiovascular and/or cerebrovascular diseases （P =0.049） were the independent factors relating to RT values in CAPD patients （R2adj =0.326, P〈0.05）. Conclusions RT is longer in CAPD patients than in healthy people. Age, education level, nutrition status, history of cardiovascular and/or cerebrovascular diseases are the factors influencing RT value in CAPD patients. Therefore, lagged RT may have impact on rehabilitation in these patients.