保心包贴膜治疗冠心病稳定型心绞痛40例临床观察

Clinic Observation of Baoxinbao Film in Treatment of Coronary Heart Disease with Stable Angina Pectoris

目的:为观察保心包贴膜治疗冠心病稳定型心绞痛的作用。方法:将76例冠心病稳定型心绞痛患者随机单盲分为治疗组(40例)和对照组(36例),分别给予保心包贴膜外敷心前区,每片4天,首次量加倍,共6片20天和消心痛10mg,每日3次口服;观察治疗前后血清ET和NO水平。结果:治疗组心绞痛总有效率为85％,心电图总有效率为67.5%,均优于对照组(分别为50％和36.1％,p<0.05和0.01),并显著地改善冠心病临床症状和降低心率收缩压乘积数(均p<0.05)。NO和ET于治疗后两组均有显著改善(p<0.05,p<0.01),但以治疗组改善更为显著。结论:保心包贴膜缓解心绞痛,改善冠心病临床症状和心肌缺血作用显著,并改善ET和NO代谢失衡。

To study the effect of Baoxinbao film in treating stable angina pectoris (SAP). 76 patients with SAP were randomly divided into two groups, 40 cases in the study group and 36 cases in the control group. The levels of serum endothelin (ET) and nitric oxide (NO) before and after treat-ment were observed. The total effective rates and ECG ST-T changes of SAP were 85% and 6. 5% respectively in the study group. These results were all superior to those of the control group (p<0. 05 or p<0. 01). The weekly consumption of isosorbide dinitrate (83. 3%) and rate pressure product were reduced significantly in the treated group, as compared with that in the control group (p<0. 01 or p<0. 05). In improving symptom of CHD were significantly better in the treated group than those in the control group (p<0. 05). After treatment the metabolic im-balance of ET and NO was improved significantly in both groups (p<0. 05, p<0. 01), but the ET and NO in the treated group were improved more obviously than those in the control group (p<0. 05). Baoxinbao film was much effective for alleviating angina pectoris, improving symptom of CHD and myocardial ischemia, and improving the metabolic imbalance of ET and NO.