基于功效和物质基础的吴茱萸毒性研究思考

Research Thinking on Toxicity of Evodia Rutaecarpa(Juss)Benth Based on Efficacy and Material Basis

目的为进行基于功效和物质基础的吴茱萸系统毒性研究提供文献依据和研究思路。方法对吴茱萸历代文献古籍及近十年国内外相关文献进行整理、分析和归纳,提出符合中医药特点的中药毒性研究思路。结果历代文献古籍中记载吴茱萸的多种功效在现代药理研究中已经得到证实,但对吴茱萸"有小毒"这一记载在中药现代药理学与毒理学研究中均相对缺乏,对其毒性成分、毒性表现也未见详细描述。应进行吴茱萸产生功效和毒性的物质基础、"物质基础-功效-毒性"的相关性、毒性作用靶点、物质基础体内过程、吴茱萸"量-效-毒"之间的关系如何等规范、系列研究,同时还要在中医辨证和辨病的基础上,去合理科学地认知毒性和功效,以期为临床安全、使用吴茱萸提供科学实验依据。结论有毒中药吴茱萸的毒性研究应该放到功效和证候的背景下进行研究,而且要注重毒性物质基础的体内过程、作用途径和作用靶点,并注重基于功效和病证的"量-效-毒"关系研究。

Objective To provide literature basis and ideas for the research of systemic toxicity based on effective and toxical composition of Evodia rutaecarpa（Juss.） Benth.Methods Making the ideas which consistent with the characteristics of Tradition Chinese Medicine by collecting,analyzing and summarizing Ancient literature,books in past dynasties and related literature in recent 10 years both at home and abroad about Evodia rutaecarpa（Juss.）Benth.Results Variety efficacy of Evodia rutaecarpa（Juss.） Benth documented in ancient literature,have been confirmed in the modern pharmacological studies.But the record about Evodia rutaecarpa（Juss.） Benth ＂slight toxicity＂ relatively lack in modern toxicology studies,and its toxical composition,toxic manifestations are not described in detail.So a series of studies should be proceeded.For example,what are the material basis creating efficacy and toxicity How is the relationship between ＂material basis-efficacy-toxicity＂,what aer the target of toxical material basis,how is the process of material basis in vivo and how is the relationship between ＂dose-efficacy-toxicity＂ of Evodia rutaecarpa（Juss.） Benth,and so on.To provide scientific experimental evidence for completely and effectively using medication of Evodia rutaecarpa（Juss.） Benth in clinic.Conclusion The toxicity of Evodia of toxical TCM should be studied under the background of efficacy,but also to focus on the process in vivo,the role of pathway and target of toxical material basis,and focus on the relations of ＂dose-effect-toxicity＂ under efficacy and symptoms of a disease.