摘要
^18F-FDG是临床上应用最多、范围最广的正电子显像剂，但其对于某些肿瘤的诊断缺乏敏感性和特异性。^11C-乙酸盐与^18F-FDG相比，有不同的体内分布方式及细胞摄取机制，是近年来众多研究证实很有希望在某些方面弥补^18F—FDG显像不足的正电子显像剂。该文综述了目前^11C-乙酸盐PET或PET-CT的机制、研究领域及最新进展。
^18F-FDG is generally used for tumors＇PET, and it is the most and widest useful positron radiopharmaceutieal in the clinic. But it does not have enough sensitivity and specificity for some kinds of tumors. ^11C-acetate has different distribution in body and uptaken mechanism by cell from ^18F-FDG. Many studies have confirmed that ^11C-acetate has the potential value to make up the insufficiency of ^18F-FDG. The researches on ^11C-acetate PET or PET-CT are reviewed in this paper, including the mechanism, research area and the newest progress.
出处
《国际放射医学核医学杂志》
2011年第1期23-27,共5页
International Journal of Radiation Medicine and Nuclear Medicine
基金
天津市自然科学基金重点项目（08JCZDJC23700）
天津市高等学校科技发展基金（20080133）
