纳米金在肿瘤显像与放射治疗中的应用

The application of nanogold in tumor imaging and radiotherapy

纳米金因具有良好的表面性质和优异的生物亲和性，使其能被多种基团修饰，从而获得对肿瘤细胞的靶向性；又因其具有表面等离子共振效应等强吸收和发光特性，故可进行肿瘤显像。另外，在肿瘤放疗过程中，纳米金能够将吸收的光能转化为热能进行肿瘤局部加热，起到了放疗增敏的效果，从而减少受照剂量，减轻放疗对正常组织的伤害。该文阐述靶向修饰的纳米金在肿瘤显像和放疗中的研究进展，而纳米金在体内分布、代谢及其生物毒性有待进一步研究。

Nanogold can be modified by various groups and thus target to tumor cells because of its satisfactory surface property and excellent biological affinity, and as its surface plasmon resonance and strong absorption induced luminescence, nanogold can be used in tumor imaging, what＇s more, nanogold can transform the light absorbed into localized heat in tumor radiotherapy, which plays a radiosensitization effect, therefor reduces the radiation doses and the damage to normal tissue. This article describes the progression of researching targeted nanogold in tumor imaging and radiotherapy, but the distribution, metabolism and biotoxicity of nanogold in vivo are still not well understood.