慢性阻塞性肺疾病不同病情患者肌酸激酶水平与动脉血氧分压关系

Relationship between CK and PaO_2 among Acute and Stable COPD Patients

目的:了解慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)患者肌酸激酶水平(creatine ki-nase,CK)与动脉血氧分压(partial pressure of oxygen in artery,PaO2)之间的关系。方法:对已经确诊的COPD患者30例进行分析。患者分别于急性发作期和治疗稳定期抽取空腹静脉血和动脉血,检测CK、PaO2。结果:急性期COPD患者的血清CK和PaO2分别为(248.0±19.0)U/L和(41.0±3.3)mm Hg,明显高于稳定期组(229.0±17.5)U/L和(62.0±3.2)mm Hg,两者差异有统计学意义(t=4.094,P<0.01和t=25.161,P<0.01),CK与PaO2之间存在负相关(r=-0.606,P<0.01)。结论:CK是COPD患者病情变化的一个敏感指标,且与PaO2水平呈负相关。在临床上可用来评估COPD患者的病情程度和治疗效果。

Objective： To investigate the relationship between creatine kinase（CK） and partial pressure of oxygen in artery（PaO2）among acute and stable patients with COPD.Methods： 30 COPD patients were selected.Both fasting venous and arterial blood samples were collected for COPD patients at the acute and the stable stage separately,the concentrations of CK and PaO2 of all blood samples were examined.Results： The concentration of CK were significantly higher among acute COPD patients（248±19.0） U/L than those among stable patients（229±17.5） U/L,however,the concentration of PaO2 was significantly higher among stable COPD patients（62.0±3.2） mm Hg than that among acute patients（41.0±3.3） mm Hg.The concentration of CK negatively correlated with PaO2.Conclusion： CK is sensitive predictors of COPD status to the transition from stable to acute stage of COPD,and negatively correlated with PaO2 among these sample COPD patients.